During alcohol withdrawal, the glutamate-mediated excitotoxicity induces neuronal death, which may explain structural brain alterations observed early in abstinence in AUD patients (Tsai and Coyle, 1998). The frontal lobes being particularly rich in glutamatergic pathways (Kril et al., 1997), they are likely to be especially vulnerable alcohol brain fog to the severity of AWS. In this case, altered brain...